Abstract: Objective To explore the distribution of pathogens, bacterial drug resistance, clinical features and prognosis of bacterial meningitis (BM) in children. Methods The clinical data of children diagnosed with BM during January 2011 to July 2015 were retrospectively analyzed. Children were divided into good outcome group and poor outcome group by the outcome at discharge. The distribution of pathogens, bacterial drug resistance, clinical features, and prognosis were analyzed among different groups. Results There were included 95 children diagnosed with BM,. among whom 69 (72.6%) children had Grampositive bacterial infections with predominant Streptococcus pneumonia (43 cases, 45.3%) and 26 (27.4%) children had Gramnegative bacterial infections with predominant Escherichia coli (13 cases, 13.7%). More than 50% Streptococcus pneumonia and Escherichia coli were resisted to penicillin. The neurological complications in children with BM included subdural effusions, hydrocephalus, cerebral parenchyma injury, and hearing and visual impairment, et.al. Multivariate logistic regression analysis showed that consciousness, coma, and low level of glucose in cerebrospinal fluid were the independent risk factors for adverse outcome at discharge. Conclusion Streptococcus pneumonia and Escherichia coli were the predominant pathogens in children with BM with high resistance rate to penicillin. BM children may have varying degrees of neurological sequelae. The unconsciousness and low level of glucose in cerebrospinal fluid were associated with unfavorable outcomes at discharge.